| Rotunda Brewing | 245 W Main St | Annville | Pennsylvania | 17003-1326 | United States | brewpub | |
| Round Guys Brewing Co | 324 W Main St | Lansdale | Pennsylvania | 19446-2006 | United States | brewpub | |
| Roundabout Brewery | 4901 Butler St | Pittsburgh | Pennsylvania | 15201-2718 | United States | micro | |
| Roundback Brewery LLC | | Danville | Pennsylvania | 17821-7746 | United States | planning | |
| Roy Pitz Brewing Co | 301 Roy Pitz Ave Ste 3 | Chambersburg | Pennsylvania | 17201-1668 | United States | brewpub | |
| Rumspringa Brewing Co | 3174 Old Philadelphia Pike | Bird In Hand | Pennsylvania | 17505-9727 | United States | micro | |
| Rusty Gold Brewing | 43 W Pike St | Canonsburg | Pennsylvania | 15317 | United States | micro | |
| Rusty Rail Brewing | 5 N 8th St Ste 1 | Mifflinburg | Pennsylvania | 17844-1003 | United States | brewpub | |
| Saint Benjamin Brewing Co | 1710 N 5th St | Philadelphia | Pennsylvania | 19122-2909 | United States | micro | |
| Saint Boniface Craft Brewing Co | 1701 W Main St | Ephrata | Pennsylvania | 17522-1106 | United States | brewpub | |
| Samuel Adams Pennsylvania Brewing Co | 7880 Penn Dr | Breinigsville | Pennsylvania | 18031-1508 | United States | regional | |
| Saucony Creek Brewing Company | 15032 Kutztown Rd | Kutztown | Pennsylvania | 19530-9275 | United States | micro | |
| Second District Brewing Co. | 1939 S. Bancroft St. | Philadelphia | Pennsylvania | 19145 | United States | brewpub | |
| Selins Grove Brewing Co | 119 N Market St | Selinsgrove | Pennsylvania | 17870-1905 | United States | brewpub | |
| Separatist Beer Project | | Emmaus | Pennsylvania | 18049 | United States | proprietor | |
| Seven Sirens Brewing Company | | Bethlehem | Pennsylvania | 18015 | United States | planning | |
| Shawnee Craft Brewery | 1 River Rd | Shawnee on Delaware | Pennsylvania | 18356 | United States | brewpub | |
| ShuBrew, LLC | 210 S Main St | Zelienople | Pennsylvania | 16063-1150 | United States | brewpub | |
| Shy Bear Brewing | 35 Meadowbrook Ln | Lewistown | Pennsylvania | 17044-2802 | United States | brewpub | |
| Sly Fox Brewhouse and Eatery | 520 Kimberton Rd Pikeland Village Square | Phoenixville | Pennsylvania | 19460-4737 | United States | micro | |
| Sly Fox Brewing Co | 331 Circle of Progress Dr | Pottstown | Pennsylvania | 19464-3811 | United States | regional | |
| Snitz Creek Brewery | 7 N 9th St | Lebanon | Pennsylvania | 17046-4902 | United States | brewpub | |
| Sobel's Obscure Brewery, LLC | 954 Arona Rd | New Stanton | Pennsylvania | 15672-1109 | United States | contract | |
| Something Wicked Brewing Company | 34 Broadway Ste 200 | Hanover | Pennsylvania | 17331-3104 | United States | brewpub | |
| South County Brewing Co | 104 Mill St | Fawn Grove | Pennsylvania | 17321-9654 | United States | micro | |
| Southern Tier Brewing Co | 316 N Shore Dr | Pittsburgh | Pennsylvania | 15212-5870 | United States | brewpub | |
| Spoonwood Brewing Company | 5981 Baptist Rd | Pittsburgh | Pennsylvania | 15236-3303 | United States | brewpub | |
| Sprague Farm and Brew Works | 22043 US Highway 6 and 19 | Venango | Pennsylvania | 16440-2507 | United States | brewpub | |
| Spring Gate Brewery | 5790 Devonshire Rd | Harrisburg | Pennsylvania | 17112-3508 | United States | micro | |
| Spring House Brewery | 209 Hazel St | Lancaster | Pennsylvania | 17603-5629 | United States | micro | |
| Spring Mountain Brewing Company | | Schwenksville | Pennsylvania | 19473-1811 | United States | planning | |
| Stable 12 Brewing Company | 368 Bridge St | Phoenixville | Pennsylvania | 19460-3358 | United States | brewpub | |
| Stargazer Brewing Company | | Coatesville | Pennsylvania | 19320 | United States | planning | |
| Sterling Pig Brewery | 609 W State St | Media | Pennsylvania | 19063-2641 | United States | brewpub | |
| Stick City Brewing Company | 109 Irvine ST | Mars | Pennsylvania | 16046-0372 | United States | micro | |
| Stickman Brews | 326 N Lewis Rd # 240 | Royersford | Pennsylvania | 19468-1509 | United States | micro | |
| Stoker's Brewing Company | | Tamaqua | Pennsylvania | 18252-1405 | United States | planning | |
| Stone Church Pizza & Brewpub | 600 S Hermitage Rd | Hermitage | Pennsylvania | 16148-3629 | United States | brewpub | |
| Stoudts Brewing Co | Â Rt. 272 2800 North Reading Road | Adamstown | Pennsylvania | 19501 | United States | micro | |
| Strange Roots Experimental Ales | 4399 Gibsonia Road | Gibsonia | Pennsylvania | 15044-9343 | United States | micro | |
| Strange Roots Experimental Ales | 501 E Ohio St | Pittsburgh | Pennsylvania | 15209-2671 | United States | micro | |
| Straub Brewery | 303 Sorg St | Saint Marys | Pennsylvania | 15857-1592 | United States | regional | |
| Super Fun Time Brewing Company | | Bangor | Pennsylvania | 18013-9244 | United States | planning | |
| Susquehanna Brewing Co | 635 S Main St | Pittston | Pennsylvania | 18640-3215 | United States | micro | |
| Swashbuckler Brewing Co | 2775 Lebanon Rd | Manheim | Pennsylvania | 17545-8711 | United States | micro | |
| Tannery Run Brew Works | | Ambler | Pennsylvania | 19002-4407 | United States | planning | |
| Tattered Flag Brewery | 1 S Union St | Middletown | Pennsylvania | 17057-1446 | United States | brewpub | |
| Taylor House Brewing Co | 76 Lehigh St | Catasauqua | Pennsylvania | 18032 | United States | micro | |
| The Barley House Brewing Company LLC | 8399 Sharon Mercer Rd | Mercer | Pennsylvania | 16137 | United States | brewpub | |
| The Brewery At Hershey | 598 Schoolhouse Rd | Middletown | Pennsylvania | 17057-4029 | United States | micro | |